Matrix metalloproteinases in the central nervous system中枢神经系统中的基质金属蛋白酶 mobi 下载 fb2 夸克云 azw3 网盘 pdf pmlz

This book presents the reader with an understanding of the role played by matrix metalloproteinases （MMPs） in the normal and diseased central nervous system （CNS）。 These enzymes may be important to brain development， and may also contribute to tissue destruction， which is observed with inflammatory and degenerative conditions of the brain。 The book provides a background on the biology of MMPs， and on the stimuli and conditions that are linked to an increase in their production and activity。 It describes the targets of MMPs， which include matrix proteins such as collagen， soluble cytokines and chemokines， and cell surface receptors。 Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered。 The book also touches on studies suggesting that， in certain situations， dysregulated MMP activity and/or production may be critical to blood–brain barrier breakdown and neuronal damage。

Foreword

Ⅰ. A Brief Overview

Chapter 1. The Matrix Metalloproteinases and Their Inhibitors

Madeleine M. Handsley，Janet Cross，Jelena Gavrilovic，and Dylan R. Edwards

Ⅱ. Regulation of MMP Expression

Chapter 2. Genetic Regulation of the Matrix Metalloproteinases and Related Proteins

Tammie Roy and Elizabeth A. Milward

Chapter 3. Post-Translational Modification

Zezong Gu， Marcus Kaul，and Stuart A. Lipton

Ⅲ. MMP Function

Chapter 4. Substrates for Metalloendopeptidases in the Central Nervous System

Paul E. Gottschall，John D. Sandy，and Dieter R. Zimmermann

Chapter 5. Examples of Signalling by MMPs

Katherine Conant

Ⅳ. MMPs and TIMPs in Development

Chapter 6. Metalloproteinases in Development Breaking Things Down to Build a Nervous System

Sarah McFarlane

Chapter 7. Matrix Metalloproteinases in Myelin Formation

Peter H. Larsen and V. Wee Yong

Chapter 8. TIMPs in CNS Development

Diane Jaworski

Ⅴ. MMPs and TIMPs in Disease

Chapter 9. Matrix Metalloproteinases in Cerebral Ischemia

Monica Wetzel， Lee Anna Cunningham，and Gary A. Rosenberg

Chapter 10. Are Matrix Metalloproteinases Detrimental or Beneficial to Artherosclerosis

Vincent Lemaitre and Jeanine D'Armiento

Chapter 11. Role and Regulation of Matrix Metalloproteases in Brain Tumours

S.Sajani Lakka， and Jasti S. Rao

Chapter 12. Matrix Metalloproteinases and Related Proteins in Alzheimer’s Disease， Parkinson's Disease and Other Neurodegenerative Disorders

Carl H. Parsons，Irene Koolwijk，Tammie Roy，Cherie Roy. Daniel Johnstone，Catharine M.P. Vos， Katherine Conant，Elizabeth A. Milward

Chapter 13. Tissue Inhibitors of Matrix Metalloproteinases， Inflammation，and The Central Nervous System

Stephen J. Crocker and Iain L. Campbell

Index

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